Lyle is an Associate Professor in Medical Microbiology and Infectious Diseases at the University of Manitoba, with cross-appointments at CAPRISA, the University of Nairobi, and the Public Health Agency of Canada. His research interests include understanding the causes and consequences of inflammation in the female genital tract, HIV target cells including those that home to the gut, and HIV transmission in MSM in Kenya. He did his PhD at the University of Manitoba and his postdoctoral work at the University of Toronto, both focused on the cellular immunology of HIV transmission and pathogenesis. During his training he was based in Nairobi, Kenya and Durban, South Africa for ~13 years, where he continues to work on epidemiological and immunological studies of high-risk men and women.